| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20059735 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20033277 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20059221 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20030844 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS44000365 | HTLV-1 | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS44019580 | HTLV-1 | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS44015319 | HTLV-1 | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS44029305 | HTLV-1 | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS44013423 | HTLV-1 | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS44033052 | HTLV-1 | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | PDE4D |
|---|---|
| DrugBank ID | DB05219 |
| Drug Name | Crisaborole |
| Target ID | BE0001287 |
| UniProt ID | Q08499 |
| Regulation Type | inhibitor |
| PubMed IDs | 22841723 |
| Citations | Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y: Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012 Sep 21;586(19):3410-4. doi: 10.1016/j.febslet.2012.07.058. Epub 2012 Jul 25. |
| Groups | Approved; Investigational |
| Direct Classification | Diarylethers |
| SMILES | OB1OCC2=C1C=CC(OC1=CC=C(C=C1)C#N)=C2 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL484785 |
