| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20063989 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20020708 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS44000886 | HTLV-1 | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS44031149 | HTLV-1 | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABCA1 |
|---|---|
| DrugBank ID | DB01016 |
| Drug Name | Glyburide |
| Target ID | BE0000119 |
| UniProt ID | O95477 |
| Regulation Type | inhibitor |
| PubMed IDs | 12426219; 14660039; 15039140; 15102890; 15905177; 19805629 |
| Citations | Reddy ST, Hama S, Ng C, Grijalva V, Navab M, Fogelman AM: ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1877-83.@@Muhl H, Hofler S, Pfeilschifter J: Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. Eur J Pharmacol. 2003 Dec 15;482(1-3):325-8.@@Agassandian M, Mathur SN, Zhou J, Field FJ, Mallampalli RK: Oxysterols trigger ABCA1-mediated basolateral surfactant efflux. Am J Respir Cell Mol Biol. 2004 Aug;31(2):227-33. Epub 2004 Mar 23.@@Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M: Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul;45(7):1256-65. Epub 2004 Apr 21.@@Alder-Baerens N, Muller P, Pohl A, Korte T, Hamon Y, Chimini G, Pomorski T, Herrmann A: Headgroup-specific exposure of phospholipids in ABCA1-expressing cells. J Biol Chem. 2005 Jul 15;280(28):26321-9. Epub 2005 May 19.@@Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K, Lee WP, Hoffman HM, Dixit VM: Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol. 2009 Oct 5;187(1):61-70. doi: 10.1083/jcb.200903124. |
| Groups | Approved |
| Direct Classification | Benzenesulfonamides |
| SMILES | COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 |
| Pathways | Glibenclamide Action Pathway |
| PharmGKB | PA449782 |
| ChEMBL | CHEMBL472 |
