| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10041784 | HBV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS10041785 | HBV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30009838 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30011116 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30016681 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30016680 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30009839 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30085762 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072171 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072172 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABL1 |
|---|---|
| DrugBank ID | DB00619 |
| Drug Name | Imatinib |
| Target ID | BE0000014 |
| UniProt ID | P00519 |
| Regulation Type | inhibitor |
| PubMed IDs | 15799618; 15917650; 15949566; 16153117; 16205964 |
| Citations | Hoerth E, Kodym R: Involvment of c-Abl in the radiation-induced inhibition of myoblast differentiation. Int J Radiat Biol. 2004 Oct;80(10):729-36.@@Dewar AL, Zannettino AC, Hughes TP, Lyons AB: Inhibition of c-fms by imatinib: expanding the spectrum of treatment. Cell Cycle. 2005 Jul;4(7):851-3. Epub 2005 Jul 28.@@Agirre X, Roman-Gomez J, Vazquez I, Jimenez-Velasco A, Larrayoz MJ, Lahortiga I, Andreu EJ, Marquez J, Beltran de Heredia JM, Odero MD, Prosper F, Calasanz MJ: Coexistence of different clonal populations harboring the b3a2 (p210) and e1a2 (p190) BCR-ABL1 fusion transcripts in chronic myelogenous leukemia resistant to imatinib. Cancer Genet Cytogenet. 2005 Jul 1;160(1):22-6.@@Brueggemeier SB, Wu D, Kron SJ, Palecek SP: Protein-acrylamide copolymer hydrogels for array-based detection of tyrosine kinase activity from cell lysates. Biomacromolecules. 2005 Sep-Oct;6(5):2765-75.@@Haberler C, Gelpi E, Marosi C, Rossler K, Birner P, Budka H, Hainfellner JA: Immunohistochemical analysis of platelet-derived growth factor receptor-alpha, -beta, c-kit, c-abl, and arg proteins in glioblastoma: possible implications for patient selection for imatinib mesylate therapy. J Neurooncol. 2006 Jan;76(2):105-9. |
| Groups | Approved |
| Direct Classification | Benzanilides |
| SMILES | CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC=CC(=N3)C3=CN=CC=C3)=C(C)C=C2)CC1 |
| Pathways | Imatinib Inhibition of BCR-ABL |
| PharmGKB | PA10804 |
| ChEMBL | CHEMBL941 |
