| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10045457 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10045933 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10045934 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10040388 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10040389 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10048673 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10048563 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10048564 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10047426 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
| TVIS10047427 | HBV | ENSG00000196616.15 | protein_coding | ADH1B | No | No | 125 | D6RHZ6 P00325 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ADH1B |
|---|---|
| DrugBank ID | DB01213 |
| Drug Name | Fomepizole |
| Target ID | BE0000400 |
| UniProt ID | P00325 |
| Regulation Type | inhibitor |
| PubMed IDs | 1590750; 11391066; 2573502; 19458366; 16871118; 16946442 |
| Citations | Yin SJ, Liao CS, Chen CM, Fan FT, Lee SC: Genetic polymorphism and activities of human lung alcohol and aldehyde dehydrogenases: implications for ethanol metabolism and cytotoxicity. Biochem Genet. 1992 Apr;30(3-4):203-15.@@Eriksson CJ, Fukunaga T, Sarkola T, Chen WJ, Chen CC, Ju JM, Cheng AT, Yamamoto H, Kohlenberg-Muller K, Kimura M, Murayama M, Matsushita S, Kashima H, Higuchi S, Carr L, Viljoen D, Brooke L, Stewart T, Foroud T, Su J, Li TK, Whitfield JB: Functional relevance of human adh polymorphism. Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):157S-163S.@@Kassam JP, Tang BK, Kadar D, Kalow W: In vitro studies of human liver alcohol dehydrogenase variants using a variety of substrates. Drug Metab Dispos. 1989 Sep-Oct;17(5):567-72.@@Brent J: Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 2009 May 21;360(21):2216-23. doi: 10.1056/NEJMct0806112.@@Calello DP, Osterhoudt KC, Henretig FM: New and novel antidotes in pediatrics. Pediatr Emerg Care. 2006 Jul;22(7):523-30.@@Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF: Antidote use in the critically ill poisoned patient. J Intensive Care Med. 2006 Sep-Oct;21(5):255-77. |
| Groups | Approved; Vet_approved |
| Direct Classification | Pyrazoles |
| SMILES | CC1=CNN=C1 |
| Pathways | |
| PharmGKB | PA449697 |
| ChEMBL | CHEMBL1308 |
