| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10040030 | HBV | ENSG00000151632.18 | protein_coding | AKR1C2 | No | No | 1646 | B4DK69 P52895 |
| TVIS10059666 | HBV | ENSG00000151632.18 | protein_coding | AKR1C2 | No | No | 1646 | B4DK69 P52895 |
| TVIS30027108 | HIV | ENSG00000151632.18 | protein_coding | AKR1C2 | No | No | 1646 | B4DK69 P52895 |
| TVIS30027109 | HIV | ENSG00000151632.18 | protein_coding | AKR1C2 | No | No | 1646 | B4DK69 P52895 |
| TVIS30027110 | HIV | ENSG00000151632.18 | protein_coding | AKR1C2 | No | No | 1646 | B4DK69 P52895 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AKR1C2 |
|---|---|
| DrugBank ID | DB01586 |
| Drug Name | Ursodeoxycholic acid |
| Target ID | BE0000622 |
| UniProt ID | P52895 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 19747134; 18826220; 9973208; 24929818 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Amaral JD, Sola S, Steer CJ, Rodrigues CM: Role of nuclear steroid receptors in apoptosis. Curr Med Chem. 2009;16(29):3886-902.@@Halim M, Yee DJ, Sames D: Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng. J Am Chem Soc. 2008 Oct 29;130(43):14123-8. doi: 10.1021/ja801245y. Epub 2008 Oct 1.@@Burczynski ME, Lin HK, Penning TM: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.@@Martin N, Salazar-Cardozo C, Vercamer C, Ott L, Marot G, Slijepcevic P, Abbadie C, Pluquet O: Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes. Mol Cancer. 2014 Jun 14;13:151. doi: 10.1186/1476-4598-13-151. |
| Groups | Approved; Investigational |
| Direct Classification | Dihydroxy bile acids, alcohols and derivatives |
| SMILES | [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O |
| Pathways | |
| PharmGKB | PA451837 |
| ChEMBL | CHEMBL1551 |
