| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20043261 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20017750 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20038791 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20053858 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20053624 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20015273 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20015272 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20015536 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20014966 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS20015563 | HPV | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | BCL2 |
|---|---|
| DrugBank ID | DB01229 |
| Drug Name | Paclitaxel |
| Target ID | BE0000246 |
| UniProt ID | P10415 |
| Regulation Type | inhibitor |
| PubMed IDs | 16741658; 16895478; 17062688; 17119350; 17230521 |
| Citations | Gan Y, Wientjes MG, Au JL: Expression of basic fibroblast growth factor correlates with resistance to paclitaxel in human patient tumors. Pharm Res. 2006 Jun;23(6):1324-31. Epub 2006 Jun 8.@@Thomadaki H, Talieri M, Scorilas A: Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS. Biol Chem. 2006 Aug;387(8):1081-6.@@Yoshino T, Shiina H, Urakami S, Kikuno N, Yoneda T, Shigeno K, Igawa M: Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6116-24.@@Matsuyoshi S, Shimada K, Nakamura M, Ishida E, Konishi N: Bcl-2 phosphorylation has pathological significance in human breast cancer. Pathobiology. 2006;73(4):205-12.@@Zhang X, Wang Q, Ling MT, Wong YC, Leung SC, Wang X: Anti-apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells. Int J Cancer. 2007 May 1;120(9):1891-8. |
| Groups | Approved; Vet_approved |
| Direct Classification | Taxanes and derivatives |
| SMILES | [H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C4=CC=CC=C4)C4=CC=CC=C4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |
| Pathways | Paclitaxel Action Pathway |
| PharmGKB | PA450761 |
| ChEMBL | CHEMBL428647 |
