| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30086172 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30084988 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055183 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055184 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055185 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055186 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055187 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS20038778 | HPV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS20023449 | HPV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS44030081 | HTLV-1 | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BCR |
|---|---|
| DrugBank ID | DB01254 |
| Drug Name | Dasatinib |
| Target ID | BE0004743 |
| UniProt ID | P11274 |
| Regulation Type | inhibitor |
| PubMed IDs | 15256671; 23226582; 18180381 |
| Citations | Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL: Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004 Jul 16;305(5682):399-401.@@Reddy EP, Aggarwal AK: The ins and outs of bcr-abl inhibition. Genes Cancer. 2012 May;3(5-6):447-54. doi: 10.1177/1947601912462126.@@Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P: The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107. doi: 10.1182/blood-2007-08-104372. Epub 2008 Jan 7. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1 |
| Pathways | Dasatinib Inhibition of BCR-ABL |
| PharmGKB | PA162372878 |
| ChEMBL | CHEMBL1421 |
