| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30028376 | HIV | ENSG00000213341.11 | protein_coding | CHUK | No | No | 1147 | O15111 |
| TVIS30028377 | HIV | ENSG00000213341.11 | protein_coding | CHUK | No | No | 1147 | O15111 |
| TVIS30028378 | HIV | ENSG00000213341.11 | protein_coding | CHUK | No | No | 1147 | O15111 |
| TVIS30028379 | HIV | ENSG00000213341.11 | protein_coding | CHUK | No | No | 1147 | O15111 |
| TVIS44034669 | HTLV-1 | ENSG00000213341.11 | protein_coding | CHUK | No | No | 1147 | O15111 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHUK |
|---|---|
| DrugBank ID | DB00244 |
| Drug Name | Mesalazine |
| Target ID | BE0004655 |
| UniProt ID | O15111 |
| Regulation Type | inhibitor |
| PubMed IDs | 11151876; 12950415; 11054378 |
| Citations | Bantel H, Berg C, Vieth M, Stolte M, Kruis W, Schulze-Osthoff K: Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol. 2000 Dec;95(12):3452-7.@@Allgayer H: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:10-4.@@Weber CK, Liptay S, Wirth T, Adler G, Schmid RM: Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000 Nov;119(5):1209-18. |
| Groups | Approved |
| Direct Classification | Aminobenzoic acids |
| SMILES | NC1=CC(C(O)=O)=C(O)C=C1 |
| Pathways | |
| PharmGKB | PA450384 |
| ChEMBL | CHEMBL704 |
