| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30067560 | HIV | ENSG00000106258.16 | protein_coding | CYP3A5 | No | No | 1577 | P20815 |
| TVIS30067561 | HIV | ENSG00000106258.16 | protein_coding | CYP3A5 | No | No | 1577 | P20815 |
| TVIS30067562 | HIV | ENSG00000106258.16 | protein_coding | CYP3A5 | No | No | 1577 | P20815 |
| TVIS30067563 | HIV | ENSG00000106258.16 | protein_coding | CYP3A5 | No | No | 1577 | P20815 |
| TVIS44050640 | HTLV-1 | ENSG00000106258.16 | protein_coding | CYP3A5 | No | No | 1577 | P20815 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CYP3A5 |
|---|---|
| DrugBank ID | DB09065 |
| Drug Name | Cobicistat |
| Target ID | BE0002362 |
| UniProt ID | P20815 |
| Regulation Type | inhibitor |
| PubMed IDs | 20043009; 28627229 |
| Citations | Mathias AA, German P, Murray BP, Wei L, Jain A, West S, Warren D, Hui J, Kearney BP: Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther. 2010 Mar;87(3):322-9. doi: 10.1038/clpt.2009.228. Epub 2009 Dec 30.@@Tseng A, Hughes CA, Wu J, Seet J, Phillips EJ: Cobicistat Versus Ritonavir: Similar Pharmacokinetic Enhancers But Some Important Differences. Ann Pharmacother. 2017 Nov;51(11):1008-1022. doi: 10.1177/1060028017717018. Epub 2017 Jun 19. |
| Groups | Approved |
| Direct Classification | N-carbamoyl-alpha amino acids and derivatives |
| SMILES | CC(C)C1=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC2=CC=CC=C2)NC(=O)OCC2=CN=CS2)CC2=CC=CC=C2)=CS1 |
| Pathways | |
| PharmGKB | PA166165092 |
| ChEMBL | CHEMBL2095208 |
