| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10032741 | HBV | ENSG00000132437.18 | protein_coding | DDC | No | No | 1644 | A0A087WV24 P20711 Q53Y41 |
| TVIS20011818 | HPV | ENSG00000132437.18 | protein_coding | DDC | No | No | 1644 | A0A087WV24 P20711 Q53Y41 |
| TVIS20036608 | HPV | ENSG00000132437.18 | protein_coding | DDC | No | No | 1644 | A0A087WV24 P20711 Q53Y41 |
| TVIS20023113 | HPV | ENSG00000132437.18 | protein_coding | DDC | No | No | 1644 | A0A087WV24 P20711 Q53Y41 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | DDC |
|---|---|
| DrugBank ID | DB00190 |
| Drug Name | Carbidopa |
| Target ID | BE0002151 |
| UniProt ID | P20711 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 10934669; 11709201; 12885750; 16184369; 17241115; 11106255 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Durso R, Evans JE, Josephs E, Szabo G, Evans B, Fernandez HH, Browne TR: Variable absorption of carbidopa affects both peripheral and central levodopa metabolism. J Clin Pharmacol. 2000 Aug;40(8):854-60.@@Yee RE, Cheng DW, Huang SC, Namavari M, Satyamurthy N, Barrio JR: Blood-brain barrier and neuronal membrane transport of 6-[18F]fluoro-L-DOPA. Biochem Pharmacol. 2001 Nov 15;62(10):1409-15.@@Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, Nardin R, Freeman R: Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation. 2003 Aug 12;108(6):724-8. Epub 2003 Jul 28.@@Orlefors H, Sundin A, Lu L, Oberg K, Langstrom B, Eriksson B, Bergstrom M: Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography. Eur J Nucl Med Mol Imaging. 2006 Jan;33(1):60-5. Epub 2005 Sep 24.@@Calabrese V, Mancuso C, Ravagna A, Perluigi M, Cini C, De Marco C, Butterfield DA, Stella AM: In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state. J Neurochem. 2007 May;101(3):709-17. Epub 2007 Jan 4.@@Gilbert JA, Frederick LM, Ames MM: The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin Cancer Res. 2000 Nov;6(11):4365-72. |
| Groups | Approved |
| Direct Classification | Phenylpropanoic acids |
| SMILES | C[C@@](CC1=CC(O)=C(O)C=C1)(NN)C(O)=O |
| Pathways | |
| PharmGKB | PA448794 |
| ChEMBL | CHEMBL1201236 |
