| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44038857 | HTLV-1 | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS44045048 | HTLV-1 | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | DHFR |
|---|---|
| DrugBank ID | DB00205 |
| Drug Name | Pyrimethamine |
| Target ID | BE0000330 |
| UniProt ID | P00374 |
| Regulation Type | inhibitor |
| PubMed IDs | 12951104; 9380737; 9108546; 11752352 |
| Citations | Rastelli G, Pacchioni S, Parenti MD: Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3257-60.@@Fidock DA, Wellems TE: Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6.@@Wooden JM, Hartwell LH, Vasquez B, Sibley CH: Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum. Mol Biochem Parasitol. 1997 Mar;85(1):25-40.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational; Vet_approved |
| Direct Classification | Aminopyrimidines and derivatives |
| SMILES | CCC1=C(C(N)=NC(N)=N1)C1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA451193 |
| ChEMBL | CHEMBL36 |
