| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10051815 | HBV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30004046 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30004962 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30009443 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30013592 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30068213 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30068214 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30068215 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30068216 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
| TVIS30068217 | HIV | ENSG00000106462.12 | protein_coding | EZH2 | Yes | Yes | 2146 | A0A090N8E9 Q15910 S4S3R8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | EZH2 |
|---|---|
| DrugBank ID | DB14581 |
| Drug Name | CPI-1205 |
| Target ID | BE0009562 |
| UniProt ID | Q15910 |
| Regulation Type | inhibitor |
| PubMed IDs | 27739677 |
| Citations | Vaswani RG, Gehling VS, Dakin LA, Cook AS, Nasveschuk CG, Duplessis M, Iyer P, Balasubramanian S, Zhao F, Good AC, Campbell R, Lee C, Cantone N, Cummings RT, Normant E, Bellon SF, Albrecht BK, Harmange JC, Trojer P, Audia JE, Zhang Y, Justin N, Chen S, Wilson JR, Gamblin SJ: Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1 -(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. J Med Chem. 2016 Nov 10;59(21):9928-9941. doi: 10.1021/acs.jmedchem.6b01315. Epub 2016 Oct 28. |
| Groups | Investigational |
| Direct Classification | |
| SMILES | COC1=C(CNC(=O)C2=C(C)N([C@H](C)C3CCN(CC(F)(F)F)CC3)C3=CC=CC=C23)C(=O)NC(C)=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL |
