| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30029682 | HIV | ENSG00000149485.19 | protein_coding | FADS1 | No | No | 3992 | A0A0A0MR51 O60427 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FADS1 |
|---|---|
| DrugBank ID | DB00159 |
| Drug Name | Icosapent |
| Target ID | BE0000888 |
| UniProt ID | O60427 |
| Regulation Type | agonist |
| PubMed IDs | 10917903; 10685788; 11026622; 9610840; 9917342 |
| Citations | Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH: Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr. 2000 Aug;130(8):1925-31.@@Navarro E, Esteve M, Olive A, Klaassen J, Cabre E, Tena X, Fernandez-Banares F, Pastor C, Gassull MA: Abnormal fatty acid pattern in rheumatoid arthritis. A rationale for treatment with marine and botanical lipids. J Rheumatol. 2000 Feb;27(2):298-303.@@Engler MM, Bellenger-Germain SH, Engler MB, Narce MM, Poisson JP: Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats. Lipids. 2000 Sep;35(9):1011-5.@@Chavali SR, Zhong WW, Forse RA: Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91.@@Watts JL, Browse J: Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans. Arch Biochem Biophys. 1999 Feb 1;362(1):175-82. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Long-chain fatty acids |
| SMILES | CCC=C/CC=C/CC=C/CC=C/CC=C/CCCC(O)=O |
| Pathways | Alpha Linolenic Acid and Linoleic Acid Metabolism |
| PharmGKB | PA164746077 |
| ChEMBL | CHEMBL460026 |
