| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20053275 | HPV | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
| TVIS44018068 | HTLV-1 | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
| TVIS44051455 | HTLV-1 | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
| TVIS44051456 | HTLV-1 | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FASN |
|---|---|
| DrugBank ID | DB01083 |
| Drug Name | Orlistat |
| Target ID | BE0000959 |
| UniProt ID | P49327 |
| Regulation Type | inhibitor |
| PubMed IDs | 15026345; 19381703; 17618296 |
| Citations | Kridel SJ, Axelrod F, Rozenkrantz N, Smith JW: Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 2004 Mar 15;64(6):2070-5.@@Dowling S, Cox J, Cenedella RJ: Inhibition of fatty acid synthase by Orlistat accelerates gastric tumor cell apoptosis in culture and increases survival rates in gastric tumor bearing mice in vivo. Lipids. 2009 Jun;44(6):489-98. doi: 10.1007/s11745-009-3298-2. Epub 2009 Apr 21.@@Pemble CW 4th, Johnson LC, Kridel SJ, Lowther WT: Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. Nat Struct Mol Biol. 2007 Aug;14(8):704-9. Epub 2007 Jul 8. |
| Groups | Approved; Investigational |
| Direct Classification | Leucine and derivatives |
| SMILES | CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |
| Pathways | |
| PharmGKB | PA164776864 |
| ChEMBL | CHEMBL175247 |
