| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30018923 | HIV | ENSG00000138685.18 | protein_coding | FGF2 | Yes | No | 2247 | P09038 |
| TVIS20010887 | HPV | ENSG00000138685.18 | protein_coding | FGF2 | Yes | No | 2247 | P09038 |
| TVIS20023700 | HPV | ENSG00000138685.18 | protein_coding | FGF2 | Yes | No | 2247 | P09038 |
| TVIS44005895 | HTLV-1 | ENSG00000138685.18 | protein_coding | FGF2 | Yes | No | 2247 | P09038 |
| TVIS44035268 | HTLV-1 | ENSG00000138685.18 | protein_coding | FGF2 | Yes | No | 2247 | P09038 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FGF2 |
|---|---|
| DrugBank ID | DB00686 |
| Drug Name | Pentosan polysulfate |
| Target ID | BE0001015 |
| UniProt ID | P09038 |
| Regulation Type | antagonist |
| PubMed IDs | 10667230; 12375053; 7692072; 8738610; 17071728 |
| Citations | Zugmaier G, Favoni R, Jaeger R, Rosen N, Knabbe C: Polysulfated heparinoids selectively inactivate heparin-binding angiogenesis factors. Ann N Y Acad Sci. 1999;886:243-8.@@Mucha S, Melen-Mucha G, Stepien T, Godlewski A, Stepien H: Effects of pentosan polysulfate sodium on the estrogen-induced pituitary prolactinoma in Fischer 344 rats. Oncol Rep. 2002 Nov-Dec;9(6):1385-9.@@Pluda JM, Shay LE, Foli A, Tannenbaum S, Cohen PJ, Goldspiel BR, Adamo D, Cooper MR, Broder S, Yarchoan R: Administration of pentosan polysulfate to patients with human immunodeficiency virus-associated Kaposi's sarcoma. J Natl Cancer Inst. 1993 Oct 6;85(19):1585-92.@@McLeskey SW, Zhang L, Kharbanda S, Kurebayashi J, Lippman ME, Dickson RB, Kern FG: Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis. Breast Cancer Res Treat. 1996;39(1):103-17.@@Jerebtsova M, Wong E, Przygodzki R, Tang P, Ray PE: A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H743-50. Epub 2006 Oct 27. |
| Groups | Approved |
| Direct Classification | O-glycosyl compounds |
| SMILES | O[C@@H]1CO[C@@H](O[C@@H]2CO[C@@H](O)[C@H](OS(O)(=O)=O)[C@H]2OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O |
| Pathways | |
| PharmGKB | PA164774806 |
| ChEMBL | CHEMBL4073796 |
