| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10034192 | HBV | ENSG00000168522.13 | protein_coding | FNTA | No | No | 2339 | P49354 |
| TVIS30068878 | HIV | ENSG00000168522.13 | protein_coding | FNTA | No | No | 2339 | P49354 |
| TVIS20065833 | HPV | ENSG00000168522.13 | protein_coding | FNTA | No | No | 2339 | P49354 |
| TVIS44019983 | HTLV-1 | ENSG00000168522.13 | protein_coding | FNTA | No | No | 2339 | P49354 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FNTA |
|---|---|
| DrugBank ID | DB06448 |
| Drug Name | Lonafarnib |
| Target ID | BE0002373 |
| UniProt ID | P49354 |
| Regulation Type | inhibitor |
| PubMed IDs | 15494604; 17268526 |
| Citations | Lee HY, Moon H, Chun KH, Chang YS, Hassan K, Ji L, Lotan R, Khuri FR, Hong WK: Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells. J Natl Cancer Inst. 2004 Oct 20;96(20):1536-48.@@Medeiros BC, Landau HJ, Morrow M, Lockerbie RO, Pitts T, Eckhardt SG: The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines. Leukemia. 2007 Apr;21(4):739-46. Epub 2007 Feb 1. |
| Groups | Approved; Investigational |
| Direct Classification | Benzocycloheptapyridines |
| SMILES | NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2C3=C(CCC4=C2C(Br)=CC(Cl)=C4)C=C(Br)C=N3)CC1 |
| Pathways | |
| PharmGKB | PA166129466 |
| ChEMBL | CHEMBL298734 |
