| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44001407 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44032665 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44005586 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44014995 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44009948 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44034591 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44035256 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44035874 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
| TVIS44039097 | HTLV-1 | ENSG00000185760.18 | protein_coding | KCNQ5 | No | No | 56479 | Q9NR82 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KCNQ5 |
|---|---|
| DrugBank ID | DB04953 |
| Drug Name | Ezogabine |
| Target ID | BE0002400 |
| UniProt ID | Q9NR82 |
| Regulation Type | |
| PubMed IDs | 17184917; 12545144; 16713428 |
| Citations | Hirano K, Kuratani K, Fujiyoshi M, Tashiro N, Hayashi E, Kinoshita M: Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. Neurosci Lett. 2007 Feb 14;413(2):159-62. Epub 2006 Dec 20.@@Hermann R, Ferron GM, Erb K, Knebel N, Ruus P, Paul J, Richards L, Cnota HP, Troy S: Effects of age and sex on the disposition of retigabine. Clin Pharmacol Ther. 2003 Jan;73(1):61-70.@@Borlak J, Gasparic A, Locher M, Schupke H, Hermann R: N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II. Metabolism. 2006 Jun;55(6):711-21. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylbenzamines |
| SMILES | CCOC(=O)NC1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1 |
| Pathways | |
| PharmGKB | PA144997862 |
| ChEMBL | CHEMBL41355 |
