| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20058668 | HPV | ENSG00000168412.7 | protein_coding | MTNR1A | No | No | 4543 | P48039 |
| TVIS20058149 | HPV | ENSG00000168412.7 | protein_coding | MTNR1A | No | No | 4543 | P48039 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MTNR1A |
|---|---|
| DrugBank ID | DB01065 |
| Drug Name | Melatonin |
| Target ID | BE0000515 |
| UniProt ID | P48039 |
| Regulation Type | agonist |
| PubMed IDs | 19463840; 11752352; 15992934; 19449447; 20827520; 20674373; 19966183 |
| Citations | Radogna F, Paternoster L, De Nicola M, Cerella C, Ammendola S, Bedini A, Tarzia G, Aquilano K, Ciriolo M, Ghibelli L: Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):37-45. doi: 10.1016/j.taap.2009.05.012. Epub 2009 May 19.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Boutin JA, Audinot V, Ferry G, Delagrange P: Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci. 2005 Aug;26(8):412-9.@@Hardeland R: Melatonin: signaling mechanisms of a pleiotropic agent. Biofactors. 2009 Mar-Apr;35(2):183-92. doi: 10.1002/biof.23.@@Srinivasan V, Singh J, Pandi-Perumal SR, Brown GM, Spence DW, Cardinali DP: Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Adv Ther. 2010 Nov;27(11):796-813. doi: 10.1007/s12325-010-0065-y. Epub 2010 Sep 6.@@Carocci A, Catalano A, Lovece A, Lentini G, Duranti A, Lucini V, Pannacci M, Scaglione F, Franchini C: Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors. Bioorg Med Chem. 2010 Sep 1;18(17):6496-511. doi: 10.1016/j.bmc.2010.06.100. Epub 2010 Jul 3.@@Prendergast BJ: MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus). Endocrinology. 2010 Feb;151(2):714-21. doi: 10.1210/en.2009-0710. Epub 2009 Dec 4. |
| Groups | Approved; Nutraceutical; Vet_approved |
| Direct Classification | 3-alkylindoles |
| SMILES | COC1=CC2=C(NC=C2CCNC(C)=O)C=C1 |
| Pathways | Tryptophan Metabolism |
| PharmGKB | PA164752558 |
| ChEMBL | CHEMBL45 |
