| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS46000986 | BKPyv | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS30087171 | HIV | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS30026952 | HIV | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS20047945 | HPV | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS20037351 | HPV | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS20048036 | HPV | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS20015959 | HPV | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS44012711 | HTLV-1 | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS44002677 | HTLV-1 | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
| TVIS44048647 | HTLV-1 | ENSG00000116984.15 | protein_coding | MTR | No | No | 4548 | Q99707 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MTR |
|---|---|
| DrugBank ID | DB00116 |
| Drug Name | Tetrahydrofolic acid |
| Target ID | BE0000734 |
| UniProt ID | Q99707 |
| Regulation Type | cofactor |
| PubMed IDs | 10978155; 11169015; 11237340; 9398303; 9730838 |
| Citations | Hall DA, Jordan-Starck TC, Loo RO, Ludwig ML, Matthews RG: Interaction of flavodoxin with cobalamin-dependent methionine synthase. Biochemistry. 2000 Sep 5;39(35):10711-9.@@Fowler B: The folate cycle and disease in humans. Kidney Int Suppl. 2001 Feb;78:S221-9.@@Fu TF, di Salvo M, Schirch V: Enzymatic determination of homocysteine in cell extracts. Anal Biochem. 2001 Mar;290(2):359-65.@@Jarrett JT, Choi CY, Matthews RG: Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase. Biochemistry. 1997 Dec 16;36(50):15739-48.@@Jarrett JT, Hoover DM, Ludwig ML, Matthews RG: The mechanism of adenosylmethionine-dependent activation of methionine synthase: a rapid kinetic analysis of intermediates in reductive methylation of Cob(II)alamin enzyme. Biochemistry. 1998 Sep 8;37(36):12649-58. |
| Groups | Nutraceutical |
| Direct Classification | Glutamic acid and derivatives |
| SMILES | NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 |
| Pathways | Histidinemia; Lesch-Nyhan Syndrome (LNS); Molybdenum Cofactor Deficiency; Azathioprine Action Pathway; AICA-Ribosiduria; Purine Nucleoside Phosphorylase Deficiency; Methionine Adenosyltransferase Deficiency; Folate Malabsorption, Hereditary; Adenine Phosphoribosyltransferase Deficiency (APRT); Thioguanine Action Pathway; Mercaptopurine Action Pathway; Non-Ketotic Hyperglycinemia; Methotrexate Action Pathway; Betaine Metabolism; S-Adenosylhomocysteine (SAH) Hydrolase Deficiency; Glycine and Serine Metabolism; Adenosine Deaminase Deficiency; Xanthinuria Type II; Methionine Metabolism; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Folate Metabolism; Sarcosine Oncometabolite Pathway; Sarcosinemia; Methylenetetrahydrofolate Reductase Deficiency (MTHFRD); Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Adenylosuccinate Lyase Deficiency; Ammonia Recycling |
| PharmGKB | PA164745110 |
| ChEMBL | CHEMBL2021342 |
