| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20050388 | HPV | ENSG00000089250.20 | protein_coding | NOS1 | No | No | 4842 | A0PJJ7 B3VK56 P29475 |
| TVIS20050392 | HPV | ENSG00000089250.20 | protein_coding | NOS1 | No | No | 4842 | A0PJJ7 B3VK56 P29475 |
| TVIS20021051 | HPV | ENSG00000089250.20 | protein_coding | NOS1 | No | No | 4842 | A0PJJ7 B3VK56 P29475 |
| TVIS44034700 | HTLV-1 | ENSG00000089250.20 | protein_coding | NOS1 | No | No | 4842 | A0PJJ7 B3VK56 P29475 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NOS1 |
|---|---|
| DrugBank ID | DB00843 |
| Drug Name | Donepezil |
| Target ID | BE0000067 |
| UniProt ID | P29475 |
| Regulation Type | inhibitor |
| PubMed IDs | 20153342; 18580182; 29273047 |
| Citations | Hwang J, Hwang H, Lee HW, Suk K: Microglia signaling as a target of donepezil. Neuropharmacology. 2010 Jun;58(7):1122-9. doi: 10.1016/j.neuropharm.2010.02.003. Epub 2010 Feb 11.@@Nakahata K, Kinoshita H, Hama-Tomioka K, Ishida Y, Matsuda N, Hatakeyama N, Haba M, Kondo T, Hatano Y: Cholinesterase inhibitor donepezil dilates cerebral parenchymal arterioles via the activation of neuronal nitric oxide synthase. Anesthesiology. 2008 Jul;109(1):124-9. doi: 10.1097/ALN.0b013e31817c0316.@@Haraguchi Y, Mizoguchi Y, Ohgidani M, Imamura Y, Murakawa-Hirachi T, Nabeta H, Tateishi H, Kato TA, Monji A: Donepezil suppresses intracellular Ca(2+) mobilization through the PI3K pathway in rodent microglia. J Neuroinflammation. 2017 Dec 22;14(1):258. doi: 10.1186/s12974-017-1033-0. |
| Groups | Approved |
| Direct Classification | N-benzylpiperidines |
| SMILES | COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1 |
| Pathways | |
| PharmGKB | PA449394 |
| ChEMBL | CHEMBL502 |
