| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44031602 | HTLV-1 | ENSG00000124588.22 | protein_coding | NQO2 | No | No | 4835 | P16083 Q5TD07 |
| TVIS44003985 | HTLV-1 | ENSG00000124588.22 | protein_coding | NQO2 | No | No | 4835 | P16083 Q5TD07 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NQO2 |
|---|---|
| DrugBank ID | DB00170 |
| Drug Name | Menadione |
| Target ID | BE0000220 |
| UniProt ID | P16083 |
| Regulation Type | |
| PubMed IDs | 12351651; 15078100; 10433694; 16765324; 15733542 |
| Citations | Long DJ 2nd, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, Barrios R, Jaiswal AK: Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J Biol Chem. 2002 Nov 29;277(48):46131-9. Epub 2002 Sep 25.@@Kwiek JJ, Haystead TA, Rudolph J: Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. Biochemistry. 2004 Apr 20;43(15):4538-47.@@Foster CE, Bianchet MA, Talalay P, Zhao Q, Amzel LM: Crystal structure of human quinone reductase type 2, a metalloflavoprotein. Biochemistry. 1999 Aug 3;38(31):9881-6.@@Celli CM, Tran N, Knox R, Jaiswal AK: NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Biochem Pharmacol. 2006 Jul 28;72(3):366-76. Epub 2006 May 4.@@Boutin JA, Chatelain-Egger F, Vella F, Delagrange P, Ferry G: Quinone reductase 2 substrate specificity and inhibition pharmacology. Chem Biol Interact. 2005 Feb 10;151(3):213-28. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Naphthoquinones |
| SMILES | CC1=CC(=O)C2=CC=CC=C2C1=O |
| Pathways | |
| PharmGKB | PA450358 |
| ChEMBL | CHEMBL590 |
