| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30083502 | HIV | ENSG00000171867.18 | protein_coding | PRNP | No | No | 5621 | F7VJQ1 P04156 Q53YK7 |
| TVIS30052962 | HIV | ENSG00000171867.18 | protein_coding | PRNP | No | No | 5621 | F7VJQ1 P04156 Q53YK7 |
| TVIS30052963 | HIV | ENSG00000171867.18 | protein_coding | PRNP | No | No | 5621 | F7VJQ1 P04156 Q53YK7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PRNP |
|---|---|
| DrugBank ID | DB09130 |
| Drug Name | Copper |
| Target ID | BE0008989 |
| UniProt ID | F7VJQ1 |
| Regulation Type | |
| PubMed IDs | 16824036; 16831968; 16990274; 17257012; 19236027; 19697239; 22791135 |
| Citations | Wells MA, Jackson GS, Jones S, Hosszu LL, Craven CJ, Clarke AR, Collinge J, Waltho JP: A reassessment of copper(II) binding in the full-length prion protein. Biochem J. 2006 Nov 1;399(3):435-44.@@Merle U, Stremmel W, Gessner R: Influence of homozygosity for methionine at codon 129 of the human prion gene on the onset of neurological and hepatic symptoms in Wilson disease. Arch Neurol. 2006 Jul;63(7):982-5.@@Shiraishi N, Utsunomiya H, Nishikimi M: Combination of NADPH and copper ions generates proteinase K-resistant aggregates from recombinant prion protein. J Biol Chem. 2006 Nov 17;281(46):34880-7. Epub 2006 Sep 21.@@Shearer J, Soh P: The copper(II) adduct of the unstructured region of the amyloidogenic fragment derived from the human prion protein is redox-active at physiological pH. Inorg Chem. 2007 Feb 5;46(3):710-9.@@Valensin G, Molteni E, Valensin D, Taraszkiewicz M, Kozlowski H: Molecular dynamics study of the Cu2+ binding-induced "structuring" of the N-terminal domain of human prion protein. J Phys Chem B. 2009 Mar 19;113(11):3277-9. doi: 10.1021/jp901030a.@@Pushie MJ, Vogel HJ: A potential mechanism for Cu2+ reduction, beta-cleavage, and beta-sheet initiation within the N-terminal domain of the prion protein: insights from density functional theory and molecular dynamics calculations. J Toxicol Environ Health A. 2009;72(17-18):1040-59. doi: 10.1080/15287390903084389.@@Remelli M, Valensin D, Toso L, Gralka E, Guerrini R, Marzola E, Kozlowski H: Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein. Metallomics. 2012 Aug;4(8):794-806. doi: 10.1039/c2mt20060k. Epub 2012 Jul 13. |
| Groups | Approved; Investigational |
| Direct Classification | Homogeneous transition metal compounds |
| SMILES | [Cu] |
| Pathways | |
| PharmGKB | PA449114 |
| ChEMBL |
