| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44008777 | HTLV-1 | ENSG00000101470.10 | protein_coding | TNNC2 | No | No | 7125 | C9J7T9 P02585 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TNNC2 |
|---|---|
| DrugBank ID | DB01373 |
| Drug Name | Calcium |
| Target ID | BE0003566 |
| UniProt ID | P02585 |
| Regulation Type | agonist |
| PubMed IDs | 21250664; 21035455; 20801130; 20371872 |
| Citations | Martin SR, Avella G, Adrover M, de Nicola GF, Bullard B, Pastore A: Binding properties of the calcium-activated F2 isoform of Lethocerus troponin C. Biochemistry. 2011 Mar 22;50(11):1839-47. doi: 10.1021/bi102076s. Epub 2011 Feb 10.@@Kreutziger KL, Piroddi N, McMichael JT, Tesi C, Poggesi C, Regnier M: Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle. J Mol Cell Cardiol. 2011 Jan;50(1):165-74. doi: 10.1016/j.yjmcc.2010.10.025. Epub 2010 Oct 28.@@Robertson IM, Sun YB, Li MX, Sykes BD: A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex. J Mol Cell Cardiol. 2010 Dec;49(6):1031-41. doi: 10.1016/j.yjmcc.2010.08.019. Epub 2010 Aug 27.@@Dweck D, Reynaldo DP, Pinto JR, Potter JD: A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding. J Biol Chem. 2010 Jun 4;285(23):17371-9. doi: 10.1074/jbc.M109.064105. Epub 2010 Apr 6. |
| Groups | Nutraceutical |
| Direct Classification | |
| SMILES | [Ca] |
| Pathways | Lidocaine (Antiarrhythmic) Action Pathway; Reteplase Action Pathway; Arachidonic Acid Metabolism; Oxaprozin Action Pathway; Ardeparin Action Pathway; Heparin Action Pathway; Mefenamic Acid Action Pathway; Bromfenac Action Pathway; Riboflavin Metabolism; Alprenolol Action Pathway; Naproxen Action Pathway; Procainamide (Antiarrhythmic) Action Pathway; Sphingolipid Metabolism; Tranexamic Acid Action Pathway; Xanthine Dehydrogenase Deficiency (Xanthinuria); Meloxicam Action Pathway; Phenprocoumon Action Pathway; Streptokinase Action Pathway; Phenylketonuria; Gaucher Disease; Fc Epsilon Receptor I Signaling in Mast Cells; Ketorolac Action Pathway; Androgen and Estrogen Metabolism; Acetylsalicylic Acid Action Pathway; Bivalirudin Action Pathway; Aprotinin Action Pathway; Alpha Linolenic Acid and Linoleic Acid Metabolism; Malate-Aspartate Shuttle; Folate Metabolism; Adenylosuccinate Lyase Deficiency |
| PharmGKB | PA164712582 |
| ChEMBL |
