| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20000787 | HPV | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS20010614 | HPV | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS20006685 | HPV | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS20062059 | HPV | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS20062240 | HPV | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS44033258 | HTLV-1 | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS44016804 | HTLV-1 | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS44015123 | HTLV-1 | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
| TVIS44012059 | HTLV-1 | ENSG00000146648.21 | protein_coding | EGFR | Yes | No | 1956 | E7BSV0 P00533 Q504U8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | EGFR |
|---|---|
| DrugBank ID | DB12114 |
| Drug Name | Poziotinib |
| Target ID | BE0000767 |
| UniProt ID | P00533 |
| Regulation Type | inhibitor |
| PubMed IDs | 27188206 |
| Citations | Han JY, Lee KH, Kim SW, Min YJ, Cho E, Lee Y, Lee SH, Kim HY, Lee GK, Nam BH, Han H, Jung J, Lee JS: A Phase II Study of Poziotinib in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma Who Have Acquired Resistance to EGFR-Tyrosine Kinase Inhibitors. Cancer Res Treat. 2017 Jan;49(1):10-19. doi: 10.4143/crt.2016.058. Epub 2016 May 3. |
| Groups | Investigational |
| Direct Classification | Quinazolinamines |
| SMILES | COC1=C(OC2CCN(CC2)C(=O)C=C)C=C2C(NC3=CC=C(Cl)C(Cl)=C3F)=NC=NC2=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3545154 |
