| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10039868 | HBV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS10050136 | HBV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20005760 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20042749 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20014551 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20014552 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20014553 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20014554 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20014782 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
| TVIS20014795 | HPV | ENSG00000165029.17 | protein_coding | ABCA1 | No | No | 19 | B2RUU2 B7XCW9 O95477 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABCA1 |
|---|---|
| DrugBank ID | DB01599 |
| Drug Name | Probucol |
| Target ID | BE0000119 |
| UniProt ID | O95477 |
| Regulation Type | inhibitor |
| PubMed IDs | 15514211; 19075491; 20075420; 1868500; 19427182; 19458386 |
| Citations | Favari E, Zanotti I, Zimetti F, Ronda N, Bernini F, Rothblat GH: Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2345-50. Epub 2004 Oct 28.@@Yamamoto A: A uniqe antilipidemic drug--probucol. J Atheroscler Thromb. 2008 Dec;15(6):304-5. Epub 2008 Dec 11.@@de la Llera-Moya M, Drazul-Schrader D, Asztalos BF, Cuchel M, Rader DJ, Rothblat GH: The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):796-801. doi: 10.1161/ATVBAHA.109.199158. Epub 2010 Jan 14.@@Sirtori CR, Manzoni C, Lovati MR: Mechanisms of lipid-lowering agents. Cardiology. 1991;78(3):226-35.@@Shichiri M, Takanezawa Y, Rotzoll DE, Yoshida Y, Kokubu T, Ueda K, Tamai H, Arai H: ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. J Nutr Biochem. 2010 May;21(5):451-6. doi: 10.1016/j.jnutbio.2009.02.002. Epub 2009 May 7.@@Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S: Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis. J Lipid Res. 2009 Nov;50(11):2299-305. doi: 10.1194/jlr.M900122-JLR200. Epub 2009 May 20. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylpropanes |
| SMILES | CC(C)(SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C |
| Pathways | |
| PharmGKB | PA451107 |
| ChEMBL | CHEMBL608 |
