| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30087129 | HIV | ENSG00000168398.7 | protein_coding | BDKRB2 | No | No | 624 | P30411 |
| TVIS30037161 | HIV | ENSG00000168398.7 | protein_coding | BDKRB2 | No | No | 624 | P30411 |
| TVIS20051942 | HPV | ENSG00000168398.7 | protein_coding | BDKRB2 | No | No | 624 | P30411 |
| TVIS44006925 | HTLV-1 | ENSG00000168398.7 | protein_coding | BDKRB2 | No | No | 624 | P30411 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BDKRB2 |
|---|---|
| DrugBank ID | DB06549 |
| Drug Name | Labradimil |
| Target ID | BE0003513 |
| UniProt ID | P30411 |
| Regulation Type | agonist |
| PubMed IDs | 11160651; 11160652; 11286321; 31874445 |
| Citations | Emerich DF, Snodgrass P, Dean RL, Lafreniere D, Agostino M, Wiens T, Xiong H, Hasler B, Marsh J, Pink M, Kim BS, Bartus RT: Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy. J Pharmacol Exp Ther. 2001 Feb;296(2):623-31.@@Emerich DF, Dean RL, Snodgrass P, Lafreniere D, Agostino M, Wiens T, Xiong H, Hasler B, Marsh J, Pink M, Kim BS, Perdomo B, Bartus RT: Bradykinin modulation of tumor vasculature: II. activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors. J Pharmacol Exp Ther. 2001 Feb;296(2):632-41.@@Emerich DF, Dean RL, Osborn C, Bartus RT: The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier: from concept to clinical evaluation. Clin Pharmacokinet. 2001;40(2):105-23. doi: 10.2165/00003088-200140020-00003.@@Gholamreza-Fahimi E, Bisha M, Hahn J, Strassen U, Krybus M, Khosravani F, Hoffmann TK, Hohlfeld T, Greve J, Bas M, Twarock S, Kojda G: Cyclooxygenase activity in bradykinin-induced dermal extravasation. A study in mice and humans. Biomed Pharmacother. 2020 Mar;123:109797. doi: 10.1016/j.biopha.2019.109797. Epub 2019 Dec 23. |
| Groups | Investigational |
| Direct Classification | Oligopeptides |
| SMILES | COC1=CC=C(C[C@@H](CN[C@@H](CCCN=C(N)N)C(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CS2)NC(=O)CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2105864 |
