| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10050536 | HBV | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS10049990 | HBV | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS30008799 | HIV | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS20012134 | HPV | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS20024726 | HPV | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS44004386 | HTLV-1 | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS44038861 | HTLV-1 | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS44038892 | HTLV-1 | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS44038891 | HTLV-1 | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
| TVIS44045060 | HTLV-1 | ENSG00000228716.7 | protein_coding | DHFR | No | No | 1719 | B4DM58 P00374 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | DHFR |
|---|---|
| DrugBank ID | DB00563 |
| Drug Name | Methotrexate |
| Target ID | BE0000330 |
| UniProt ID | P00374 |
| Regulation Type | inhibitor |
| PubMed IDs | 16971132; 17333344; 17130456; 11752352; 16647263; 16936229; 24284432 |
| Citations | Al-Rashood ST, Aboldahab IA, Nagi MN, Abouzeid LA, Abdel-Aziz AA, Abdel-Hamide SG, Youssef KM, Al-Obaid AM, El-Subbagh HI: Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs. Bioorg Med Chem. 2006 Dec 15;14(24):8608-21. Epub 2006 Sep 12.@@Assaraf YG: Molecular basis of antifolate resistance. Cancer Metastasis Rev. 2007 Mar;26(1):153-81.@@Bennett B, Langan P, Coates L, Mustyakimov M, Schoenborn B, Howell EE, Dealwis C: Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18493-8. Epub 2006 Nov 27.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Totani K, Matsuo I, Ihara Y, Ito Y: High-mannose-type glycan modifications of dihydrofolate reductase using glycan-methotrexate conjugates. Bioorg Med Chem. 2006 Aug 1;14(15):5220-9. Epub 2006 May 2.@@Uga H, Kuramori C, Ohta A, Tsuboi Y, Tanaka H, Hatakeyama M, Yamaguchi Y, Takahashi T, Kizaki M, Handa H: A new mechanism of methotrexate action revealed by target screening with affinity beads. Mol Pharmacol. 2006 Nov;70(5):1832-9. Epub 2006 Aug 25.@@Inoue K, Yuasa H: Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy. Drug Metab Pharmacokinet. 2014;29(1):12-9. Epub 2013 Nov 26. |
| Groups | Approved |
| Direct Classification | Glutamic acid and derivatives |
| SMILES | CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
| Pathways | Methotrexate Action Pathway |
| PharmGKB | PA450428 |
| ChEMBL | CHEMBL34259 |
