| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30047786 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047787 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047788 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047789 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047790 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30021427 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047791 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047792 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047793 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047794 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | DNMT1 |
|---|---|
| DrugBank ID | DB01035 |
| Drug Name | Procainamide |
| Target ID | BE0000892 |
| UniProt ID | P26358 |
| Regulation Type | other |
| PubMed IDs | 15188362; 15795105; 16230360; 2066944 |
| Citations | Oelke K, Lu Q, Richardson D, Wu A, Deng C, Hanash S, Richardson B: Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum. 2004 Jun;50(6):1850-60.@@Januchowski R, Jagodzinski PP: Effect of 5-azacytidine and procainamide on CD3-zeta chain expression in Jurkat T cells. Biomed Pharmacother. 2005 Apr;59(3):122-6.@@Lee BH, Yegnasubramanian S, Lin X, Nelson WG: Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005 Dec 9;280(49):40749-56. Epub 2005 Oct 17.@@Scheinbart LS, Johnson MA, Gross LA, Edelstein SR, Richardson BC: Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol. 1991 Apr;18(4):530-4. |
| Groups | Approved |
| Direct Classification | Aminobenzamides |
| SMILES | CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 |
| Pathways | Procainamide (Antiarrhythmic) Action Pathway |
| PharmGKB | PA451108 |
| ChEMBL | CHEMBL640 |
