| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44027839 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
| TVIS44027840 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
| TVIS44027841 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
| TVIS44018318 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
| TVIS44014010 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
| TVIS44002123 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
| TVIS44035933 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
| TVIS44051687 | HTLV-1 | ENSG00000171189.18 | protein_coding | GRIK1 | No | No | 2897 | E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GRIK1 |
|---|---|
| DrugBank ID | DB00273 |
| Drug Name | Topiramate |
| Target ID | BE0009793 |
| UniProt ID | Q16478 |
| Regulation Type | antagonist |
| PubMed IDs | 12724156; 12904467; 15111016; 19417176 |
| Citations | Rogawski MA, Gryder D, Castaneda D, Yonekawa W, Banks MK, Lia H: GluR5 kainate receptors, seizures, and the amygdala. Ann N Y Acad Sci. 2003 Apr;985:150-62.@@Gryder DS, Rogawski MA: Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. J Neurosci. 2003 Aug 6;23(18):7069-74.@@Kaminski RM, Banerjee M, Rogawski MA: Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104.@@Braga MF, Aroniadou-Anderjaska V, Li H, Rogawski MA: Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 (GluR5) kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons. J Pharmacol Exp Ther. 2009 Aug;330(2):558-66. doi: 10.1124/jpet.109.153908. Epub 2009 May 5. |
| Groups | Approved |
| Direct Classification | Dioxolopyrans |
| SMILES | [H][C@@]12CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@]3([H])[C@]1([H])OC(C)(C)O2 |
| Pathways | |
| PharmGKB | PA451728 |
| ChEMBL | CHEMBL220492 |
