| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10016124 | HBV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS10004445 | HBV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS10026818 | HBV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS10025174 | HBV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS10026819 | HBV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS10035476 | HBV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS10026820 | HBV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS30085899 | HIV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS30032215 | HIV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20008358 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | GRIN2B |
|---|---|
| DrugBank ID | DB00502 |
| Drug Name | Haloperidol |
| Target ID | BE0000417 |
| UniProt ID | Q13224 |
| Regulation Type | antagonist |
| PubMed IDs | 16407246; 17092607; 17588330; 11752352; 11741727; 11102491; 9572299 |
| Citations | Hattori K, Uchino S, Isosaka T, Maekawa M, Iyo M, Sato T, Kohsaka S, Yagi T, Yuasa S: Fyn is required for haloperidol-induced catalepsy in mice. J Biol Chem. 2006 Mar 17;281(11):7129-35. Epub 2006 Jan 10.@@Zhuravliova E, Barbakadze T, Natsvlishvili N, Mikeladze DG: Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity. Neurochem Int. 2007 Jun;50(7-8):976-82. Epub 2006 Nov 7.@@Gu WH, Yang S, Shi WX, Zhen XC, Jin GZ: Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine. Acta Pharmacol Sin. 2007 Jul;28(7):953-8.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Steinmetz RD, Fava E, Nicotera P, Steinhilber D: A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. J Neurosci Methods. 2002 Jan 15;113(1):99-110.@@Sinor JD, Du S, Venneti S, Blitzblau RC, Leszkiewicz DN, Rosenberg PA, Aizenman E: NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. J Neurosci. 2000 Dec 1;20(23):8831-7.@@Gallagher MJ, Huang H, Lynch DR: Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions. J Neurochem. 1998 May;70(5):2120-8. |
| Groups | Approved |
| Direct Classification | Alkyl-phenylketones |
| SMILES | OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA449841 |
| ChEMBL | CHEMBL54 |
