| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30068749 | HIV | ENSG00000104687.14 | protein_coding | GSR | No | No | 2936 | P00390 |
| TVIS30068750 | HIV | ENSG00000104687.14 | protein_coding | GSR | No | No | 2936 | P00390 |
| TVIS20063279 | HPV | ENSG00000104687.14 | protein_coding | GSR | No | No | 2936 | P00390 |
| TVIS44009882 | HTLV-1 | ENSG00000104687.14 | protein_coding | GSR | No | No | 2936 | P00390 |
| TVIS44039967 | HTLV-1 | ENSG00000104687.14 | protein_coding | GSR | No | No | 2936 | P00390 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GSR |
|---|---|
| DrugBank ID | DB00262 |
| Drug Name | Carmustine |
| Target ID | BE0000648 |
| UniProt ID | P00390 |
| Regulation Type | inhibitor |
| PubMed IDs | 10378469; 12477282; 1312851; 1394620; 15104113; 15321730; 3806383; 6094175 |
| Citations | Akella SS, Harris C: Pyridine nucleotide flux and glutathione oxidation in the cultured rat conceptus. Reprod Toxicol. 1999 May-Jun;13(3):203-13.@@Kirsch JD, Yi AK, Spitz DR, Krieg AM: Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA. Antisense Nucleic Acid Drug Dev. 2002 Oct;12(5):327-40.@@Vallyathan V, Mega JF, Shi X, Dalal NS: Enhanced generation of free radicals from phagocytes induced by mineral dusts. Am J Respir Cell Mol Biol. 1992 Apr;6(4):404-13.@@Brodie AE, Reed DJ: Glutathione disulfide reduction in tumor mitochondria after t-butyl hydroperoxide treatment. Chem Biol Interact. 1992 Sep 28;84(2):125-32.@@Jopperi-Davis KS, Park MS, Rogers LK, Backes CH Jr, Lim IK, Smith CV: Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats. Toxicol Lett. 2004 Mar 7;147(3):219-28.@@Doroshenko N, Doroshenko P: The glutathione reductase inhibitor carmustine induces an influx of Ca2+ in PC12 cells. Eur J Pharmacol. 2004 Aug 16;497(1):17-24.@@Powell SR, Puglia CD: Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity. J Pharmacol Exp Ther. 1987 Jan;240(1):111-7.@@Puglia CD, Powell SR: Inhibition of cellular antioxidants: a possible mechanism of toxic cell injury. Environ Health Perspect. 1984 Aug;57:307-11. |
| Groups | Approved; Investigational |
| Direct Classification | Nitrosoureas |
| SMILES | ClCCNC(=O)N(CCCl)N=O |
| Pathways | |
| PharmGKB | PA448810 |
| ChEMBL | CHEMBL513 |
