Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS42001682EBVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30006844HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30012119HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30012120HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30002480HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30002481HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30006845HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30012121HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30006846HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TVIS30006847HIVENSG00000005844.19protein_codingITGALNoNo3683P20701
TCGA Plot Options ▼
Drug Information ▼
GeneITGAL
DrugBank IDDB00227
Drug NameLovastatin
Target IDBE0000516
UniProt IDP20701
Regulation Typeinhibitor
PubMed IDs10493852; 11385505; 15822172
CitationsKallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J Mol Biol. 1999 Sep 10;292(1):1-9.@@Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058.@@Liao JK, Laufs U: Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89-118. doi: 10.1146/annurev.pharmtox.45.120403.095748.
GroupsApproved; Investigational
Direct ClassificationDelta valerolactones
SMILES[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC
PathwaysLovastatin Action Pathway
PharmGKBPA450272
ChEMBLCHEMBL503