| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30014909 | HIV | ENSG00000133703.14 | protein_coding | KRAS | Yes | No | 3845 | L7RSL8 P01116 |
| TVIS30032316 | HIV | ENSG00000133703.14 | protein_coding | KRAS | Yes | No | 3845 | L7RSL8 P01116 |
| TVIS30032317 | HIV | ENSG00000133703.14 | protein_coding | KRAS | Yes | No | 3845 | L7RSL8 P01116 |
| TVIS30032318 | HIV | ENSG00000133703.14 | protein_coding | KRAS | Yes | No | 3845 | L7RSL8 P01116 |
| TVIS30032319 | HIV | ENSG00000133703.14 | protein_coding | KRAS | Yes | No | 3845 | L7RSL8 P01116 |
| TVIS20043514 | HPV | ENSG00000133703.14 | protein_coding | KRAS | Yes | No | 3845 | L7RSL8 P01116 |
| TVIS44010711 | HTLV-1 | ENSG00000133703.14 | protein_coding | KRAS | Yes | No | 3845 | L7RSL8 P01116 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KRAS |
|---|---|
| DrugBank ID | DB15568 |
| Drug Name | Adagrasib |
| Target ID | BE0004071 |
| UniProt ID | P01116 |
| Regulation Type | inhibitor |
| PubMed IDs | 31658955 |
| Citations | Christensen JG, Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue JY, Gatto S, Fernandez-Banet J, Pavlicek A, Velastegui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Janne PA, Olson P: The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients. Cancer Discov. 2019 Oct 28. pii: 2159-8290.CD-19-1167. doi: 10.1158/2159-8290.CD-19-1167. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | [H][C@@]1(COC2=NC3=C(CCN(C3)C3=CC=CC4=C3C(Cl)=CC=C4)C(=N2)N2CCN(C(=O)C(F)=C)[C@@]([H])(CC#N)C2)CCCN1C |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL4594350 |
