| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10025415 | HBV | ENSG00000257335.8 | protein_coding | MGAM | Yes | No | 8972 | E7ER45 O43451 |
| TVIS30080980 | HIV | ENSG00000257335.8 | protein_coding | MGAM | Yes | No | 8972 | E7ER45 O43451 |
| TVIS20062222 | HPV | ENSG00000257335.8 | protein_coding | MGAM | Yes | No | 8972 | E7ER45 O43451 |
| TVIS20031824 | HPV | ENSG00000257335.8 | protein_coding | MGAM | Yes | No | 8972 | E7ER45 O43451 |
| TVIS44022679 | HTLV-1 | ENSG00000257335.8 | protein_coding | MGAM | Yes | No | 8972 | E7ER45 O43451 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MGAM |
|---|---|
| DrugBank ID | DB04878 |
| Drug Name | Voglibose |
| Target ID | BE0000837 |
| UniProt ID | O43451 |
| Regulation Type | inhibitor |
| PubMed IDs | 16713439; 11752352; 19568704; 20025554; 20351564; 19281809 |
| Citations | Satoh N, Shimatsu A, Yamada K, Aizawa-Abe M, Suganami T, Kuzuya H, Ogawa Y: An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients. Metabolism. 2006 Jun;55(6):786-93.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Matsumura M, Monden T, Miyashita Y, Kawagoe Y, Shimizu H, Nakatani Y, Domeki N, Yanagi K, Ikeda S, Kasai K: Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients. Adv Ther. 2009 Jun;26(6):660-6. doi: 10.1007/s12325-009-0040-7. Epub 2009 Jun 30.@@Abe M, Okada K, Maruyama T, Maruyama N, Matsumoto K: Combination therapy with mitiglinide and voglibose improves glycemic control in type 2 diabetic patients on hemodialysis. Expert Opin Pharmacother. 2010 Feb;11(2):169-76. doi: 10.1517/14656560903530683.@@Iwasa M, Kobayashi H, Yasuda S, Kawamura I, Sumi S, Yamada Y, Shiraki T, Yamaki T, Ushikoshi H, Aoyama T, Nishigaki K, Takemura G, Fujiwara T, Fujiwara H, Minatoguchi S: Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits. J Cardiovasc Pharmacol. 2010 Jun;55(6):625-34. doi: 10.1097/FJC.0b013e3181dcd240.@@Fujimori Y, Katsuno K, Ojima K, Nakashima I, Nakano S, Ishikawa-Takemura Y, Kusama H, Isaji M: Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats. Eur J Pharmacol. 2009 May 1;609(1-3):148-54. doi: 10.1016/j.ejphar.2009.03.007. Epub 2009 Mar 10. |
| Groups | Investigational |
| Direct Classification | Aminocyclitols |
| SMILES | OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |
| Pathways | |
| PharmGKB | PA164752433 |
| ChEMBL | CHEMBL476960 |
