| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44050822 | HTLV-1 | ENSG00000122884.13 | protein_coding | P4HA1 | No | No | 5033 | P13674 Q5VSQ6 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | P4HA1 |
|---|---|
| DrugBank ID | DB01275 |
| Drug Name | Hydralazine |
| Target ID | BE0000060 |
| UniProt ID | P13674 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 15192023; 2994564; 856725 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Knowles HJ, Tian YM, Mole DR, Harris AL: Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circ Res. 2004 Jul 23;95(2):162-9. Epub 2004 Jun 10.@@Murad S, Tajima S, Pinnell SR: A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts. Arch Biochem Biophys. 1985 Sep;241(2):356-63.@@Chen KH, Paz MA, Gallop PM: Collagen prolyl hydroxylation in WI-38 fibroblast cultures: action of hydralazine. In Vitro. 1977 Jan;13(1):49-54. |
| Groups | Approved |
| Direct Classification | Phthalazines |
| SMILES | NNC1=NN=CC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA449894 |
| ChEMBL | CHEMBL276832 |
