| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30006414 | HIV | ENSG00000129484.14 | protein_coding | PARP2 | No | No | 10038 | Q9UGN5 |
| TVIS30035882 | HIV | ENSG00000129484.14 | protein_coding | PARP2 | No | No | 10038 | Q9UGN5 |
| TVIS30035883 | HIV | ENSG00000129484.14 | protein_coding | PARP2 | No | No | 10038 | Q9UGN5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PARP2 |
|---|---|
| DrugBank ID | DB11760 |
| Drug Name | Talazoparib |
| Target ID | BE0003798 |
| UniProt ID | Q9UGN5 |
| Regulation Type | inhibitor |
| PubMed IDs | 26652717 |
| Citations | Wang B, Chu D, Feng Y, Shen Y, Aoyagi-Scharber M, Post LE: Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-te trahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent. J Med Chem. 2016 Jan 14;59(1):335-57. doi: 10.1021/acs.jmedchem.5b01498. Epub 2015 Dec 23. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylquinolines |
| SMILES | CN1N=CN=C1[C@@H]1[C@H](NC2=C3C1=NNC(=O)C3=CC(F)=C2)C1=CC=C(F)C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3137320 |
