| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20012344 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20011215 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20011299 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20008241 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20004650 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20004645 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20004646 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20004647 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20042972 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20059979 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PDE4D |
|---|---|
| DrugBank ID | DB01088 |
| Drug Name | Iloprost |
| Target ID | BE0001287 |
| UniProt ID | Q08499 |
| Regulation Type | inducer |
| PubMed IDs | 11551870; 12441759; 12952271; 2461561 |
| Citations | Wilkens H, Guth A, Konig J, Forestier N, Cremers B, Hennen B, Bohm M, Sybrecht GW: Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation. 2001 Sep 11;104(11):1218-22.@@Ghofrani HA, Rose F, Schermuly RT, Olschewski H, Wiedemann R, Weissmann N, Schudt C, Tenor H, Seeger W, Grimminger F: Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension. Crit Care Med. 2002 Nov;30(11):2489-92.@@Schermuly RT, Leuchte H, Ghofrani HA, Weissmann N, Rose F, Kohstall M, Olschewski H, Schudt C, Grimminger F, Seeger W, Walmrath D: Zardaverine and aerosolised iloprost in a model of acute respiratory failure. Eur Respir J. 2003 Aug;22(2):342-7.@@Grant PG, Mannarino AF, Colman RW: cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity. Proc Natl Acad Sci U S A. 1988 Dec;85(23):9071-5. |
| Groups | Approved; Investigational |
| Direct Classification | Prostaglandins and related compounds |
| SMILES | [H][C@]12C[C@@H](O)[C@H](C=C[C@@H](O)C(C)CC#CC)[C@@]1([H])CC(C2)=CCCCC(O)=O |
| Pathways | |
| PharmGKB | PA164746843 |
| ChEMBL | CHEMBL494 |
