| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42000020 | EBV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS42000021 | EBV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS10032691 | HBV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS20002754 | HPV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS20010565 | HPV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS20011236 | HPV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS20048401 | HPV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS20048060 | HPV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS20047883 | HPV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
| TVIS20047818 | HPV | ENSG00000122420.10 | protein_coding | PTGFR | No | No | 5737 | P43088 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PTGFR |
|---|---|
| DrugBank ID | DB00905 |
| Drug Name | Bimatoprost |
| Target ID | BE0000610 |
| UniProt ID | P43088 |
| Regulation Type | agonist |
| PubMed IDs | 11740958; 12222762; 14733708; 18452763; 689791; 19697832; 17724194 |
| Citations | Sharif NA, Williams GW, Kelly CR: Bimatoprost and its free acid are prostaglandin FP receptor agonists. Eur J Pharmacol. 2001 Dec 7;432(2-3):211-3.@@Sharif NA, Kelly CR, Crider JY: Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor. J Ocul Pharmacol Ther. 2002 Aug;18(4):313-24.@@Sharif NA, Kelly CR, Crider JY, Williams GW, Xu SX: Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. J Ocul Pharmacol Ther. 2003 Dec;19(6):501-15.@@Lim KS, Nau CB, O'Byrne MM, Hodge DO, Toris CB, McLaren JW, Johnson DH: Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study. Ophthalmology. 2008 May;115(5):790-795.e4. doi: 10.1016/j.ophtha.2007.07.002.@@Mintz EE: Group supervision: an experiential approach. Int J Group Psychother. 1978 Oct;28(4):467-9.@@Neacsu AM: [Receptors involved in the mechanism of action of topical prostaglandines]. Oftalmologia. 2009;53(2):3-7.@@Wan Z, Woodward DF, Cornell CL, Fliri HG, Martos JL, Pettit SN, Wang JW, Kharlamb AB, Wheeler LA, Garst ME, Landsverk KJ, Struble CS, Stamer WD: Bimatoprost, prostamide activity, and conventional drainage. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4107-15. |
| Groups | Approved; Investigational |
| Direct Classification | Prostaglandins and related compounds |
| SMILES | CCNC(=O)CCCC=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1C=C[C@@H](O)CCC1=CC=CC=C1 |
| Pathways | |
| PharmGKB | PA164748867 |
| ChEMBL | CHEMBL1200963 |
