| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20015609 | HPV | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS20018958 | HPV | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS20046087 | HPV | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS20045633 | HPV | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS20057087 | HPV | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS20068586 | HPV | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS44007166 | HTLV-1 | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS44019082 | HTLV-1 | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS44025060 | HTLV-1 | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
| TVIS44034078 | HTLV-1 | ENSG00000077092.20 | protein_coding | RARB | No | No | 5915 | P10826 Q5QHG3 Q86UC5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RARB |
|---|---|
| DrugBank ID | DB00523 |
| Drug Name | Alitretinoin |
| Target ID | BE0000206 |
| UniProt ID | P10826 |
| Regulation Type | agonist |
| PubMed IDs | 16128742; 16253547; 16297713; 16316409; 16531051; 19678713 |
| Citations | Mizuiri H, Yoshida K, Toge T, Oue N, Aung PP, Noguchi T, Yasui W: DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. Cancer Sci. 2005 Sep;96(9):571-7.@@Milliano MT, Luxon BA: Rat hepatic stellate cells become retinoid unresponsive during activation. Hepatol Res. 2005 Nov;33(3):225-33. Epub 2005 Oct 25.@@Liu Z, Zhang L, Ding F, Li J, Guo M, Li W, Wang Y, Yu Z, Zhan Q, Wu M, Liu Z: 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells. Cancer Lett. 2005 Dec 18;230(2):271-83.@@Nalbandian A, Pang AL, Rennert OM, Chan WY, Ravindranath N, Djakiew D: A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression. Differentiation. 2005 Oct;73(8):385-96.@@Husson M, Enderlin V, Delacourte A, Ghenimi N, Alfos S, Pallet V, Higueret P: Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats. Neurobiol Dis. 2006 Jul;23(1):1-10. Epub 2006 Mar 10.@@Garnock-Jones KP, Perry CM: Alitretinoin: in severe chronic hand eczema. Drugs. 2009 Aug 20;69(12):1625-34. doi: 10.2165/11202200-000000000-00000. |
| Groups | Approved; Investigational |
| Direct Classification | Retinoids |
| SMILES | CC(C=CC1=C(C)CCCC1(C)C)=CC=CC(C)=CC(O)=O |
| Pathways | Retinol Metabolism; Vitamin A Deficiency |
| PharmGKB | PA164746900 |
| ChEMBL | CHEMBL705 |
