| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20000508 | HPV | ENSG00000170989.10 | protein_coding | S1PR1 | No | No | 1901 | P21453 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | S1PR1 |
|---|---|
| DrugBank ID | DB12371 |
| Drug Name | Siponimod |
| Target ID | BE0008652 |
| UniProt ID | P21453 |
| Regulation Type | |
| PubMed IDs | 24900670; 517042; 29138536 |
| Citations | Pan S, Gray NS, Gao W, Mi Y, Fan Y, Wang X, Tuntland T, Che J, Lefebvre S, Chen Y, Chu A, Hinterding K, Gardin A, End P, Heining P, Bruns C, Cooke NG, Nuesslein-Hildesheim B: Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. doi: 10.1021/ml300396r. eCollection 2013 Mar 14.@@Gianguzza M, Dolcemascolo G: On the ultrastructure of the test cells of Ascidia malaca during oogenesis. Acta Embryol Exp (Palermo). 1979;(2):173-89.@@Gajofatto A: Spotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date. Drug Des Devel Ther. 2017 Nov 2;11:3153-3157. doi: 10.2147/DDDT.S122249. eCollection 2017. |
| Groups | Approved; Investigational |
| Direct Classification | Trifluoromethylbenzenes |
| SMILES | CCC1=CC(=CC=C1CN1CC(C1)C(O)=O)C(C)=NOCC1=CC=C(C2CCCCC2)C(=C1)C(F)(F)F |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2336071 |
