| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10011452 | HBV | ENSG00000117601.15 | protein_coding | SERPINC1 | No | No | 462 | P01008 |
| TVIS10011453 | HBV | ENSG00000117601.15 | protein_coding | SERPINC1 | No | No | 462 | P01008 |
| TVIS10021160 | HBV | ENSG00000117601.15 | protein_coding | SERPINC1 | No | No | 462 | P01008 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SERPINC1 |
|---|---|
| DrugBank ID | DB01109 |
| Drug Name | Heparin |
| Target ID | BE0000280 |
| UniProt ID | P01008 |
| Regulation Type | potentiator |
| PubMed IDs | 17537059; 17600786; 17201083; 11752352; 11278930; 10201371; 20816747; 19818773 |
| Citations | Mirow N, Zimmermann B, Maleszka A, Knobl H, Tenderich G, Koerfer R, Herberg FW: Plasma protein binding properties to immobilized heparin and heparin-albumin conjugate. Artif Organs. 2007 Jun;31(6):466-71.@@Sun W, Bandmann H, Schrader T: A fluorescent polymeric heparin sensor. Chemistry. 2007;13(27):7701-7.@@Pappalardo F, Franco A, Crescenzi G, De Simone F, Torracca L, Zangrillo A: Anticoagulation management in patients undergoing open heart surgery by activated clotting time and whole blood heparin concentration. Perfusion. 2006 Dec;21(5):285-90.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Chuang YJ, Swanson R, Raja SM, Olson ST: Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin. J Biol Chem. 2001 May 4;276(18):14961-71. Epub 2001 Feb 7.@@Petitou M, Herault JP, Bernat A, Driguez PA, Duchaussoy P, Lormeau JC, Herbert JM: Synthesis of thrombin-inhibiting heparin mimetics without side effects. Nature. 1999 Apr 1;398(6726):417-22.@@Schedin-Weiss S, Richard B, Olson ST: Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes. Arch Biochem Biophys. 2010 Dec 15;504(2):169-76. doi: 10.1016/j.abb.2010.08.021. Epub 2010 Sep 15.@@Gettins PG, Olson ST: Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement. FEBS Lett. 2009 Nov 3;583(21):3397-400. doi: 10.1016/j.febslet.2009.10.005. Epub 2009 Oct 9. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | |
| Pathways | Fc Epsilon Receptor I Signaling in Mast Cells; Heparin Action Pathway |
| PharmGKB | PA449855 |
| ChEMBL | CHEMBL1909300 |
