| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10060771 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS10060780 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS10060768 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS10060772 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS10060779 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS10060774 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS10060775 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS10060782 | HBV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS30013920 | HIV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
| TVIS30010901 | HIV | ENSG00000064651.14 | protein_coding | SLC12A2 | No | No | 6558 | B7ZM24 P55011 Q53ZR1 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC12A2 |
|---|---|
| DrugBank ID | DB00887 |
| Drug Name | Bumetanide |
| Target ID | BE0000281 |
| UniProt ID | P55011 |
| Regulation Type | inhibitor |
| PubMed IDs | 10567922; 10831596; 11292635; 11443057; 11698253 |
| Citations | Panet R, Marcus M, Atlan H: Overexpression of the Na(+)/K(+)/Cl(-) cotransporter gene induces cell proliferation and phenotypic transformation in mouse fibroblasts. J Cell Physiol. 2000 Jan;182(1):109-18.@@Evans RL, Park K, Turner RJ, Watson GE, Nguyen HV, Dennett MR, Hand AR, Flagella M, Shull GE, Melvin JE: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. J Biol Chem. 2000 Sep 1;275(35):26720-6.@@Wall SM, Fischer MP, Mehta P, Hassell KA, Park SJ: Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD. Am J Physiol Renal Physiol. 2001 May;280(5):F913-21.@@Akar F, Jiang G, Paul RJ, O'Neill WC: Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle. Am J Physiol Cell Physiol. 2001 Aug;281(2):C579-84.@@Jiang G, Klein JD, O'Neill WC: Growth factors stimulate the Na-K-2Cl cotransporter NKCC1 through a novel Cl(-)-dependent mechanism. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1948-53. |
| Groups | Approved |
| Direct Classification | Diphenylethers |
| SMILES | CCCCNC1=C(OC2=CC=CC=C2)C(=CC(=C1)C(O)=O)S(N)(=O)=O |
| Pathways | Bumetanide Action Pathway |
| PharmGKB | PA448682 |
| ChEMBL | CHEMBL1072 |
