| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10007062 | HBV | ENSG00000277893.2 | protein_coding | SRD5A2 | No | No | 6716 | P31213 |
| TVIS20054347 | HPV | ENSG00000277893.2 | protein_coding | SRD5A2 | No | No | 6716 | P31213 |
| TVIS20032353 | HPV | ENSG00000277893.2 | protein_coding | SRD5A2 | No | No | 6716 | P31213 |
| TVIS20041692 | HPV | ENSG00000277893.2 | protein_coding | SRD5A2 | No | No | 6716 | P31213 |
| TVIS44015870 | HTLV-1 | ENSG00000277893.2 | protein_coding | SRD5A2 | No | No | 6716 | P31213 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SRD5A2 |
|---|---|
| DrugBank ID | DB01216 |
| Drug Name | Finasteride |
| Target ID | BE0000585 |
| UniProt ID | P31213 |
| Regulation Type | inhibitor |
| PubMed IDs | 12773767; 16818707; 12670724; 20460827; 19707263; 19543428; 16019620 |
| Citations | Bowman CJ, Barlow NJ, Turner KJ, Wallace DG, Foster PM: Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci. 2003 Aug;74(2):393-406. Epub 2003 May 28.@@Xu Y, Dalrymple SL, Becker RE, Denmeade SR, Isaacs JT: Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Clin Cancer Res. 2006 Jul 1;12(13):4072-9.@@Ha SJ, Kim JS, Myung JW, Lee HJ, Kim JW: Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. J Dermatol Sci. 2003 Apr;31(2):135-41.@@Suzuki R, Satoh H, Ohtani H, Hori S, Sawada Y: Saturable binding of finasteride to steroid 5alpha-reductase as determinant of nonlinear pharmacokinetics. Drug Metab Pharmacokinet. 2010;25(2):208-13.@@Smith AB, Carson CC: Finasteride in the treatment of patients with benign prostatic hyperplasia: a review. Ther Clin Risk Manag. 2009 Jun;5(3):535-45. Epub 2009 Jul 12.@@Goldenberg L, So A, Fleshner N, Rendon R, Drachenberg D, Elhilali M: The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme? Can Urol Assoc J. 2009 Jun;3(3 Suppl 2):S109-14.@@Joseph MA, Jayaseelan E, Ganapathi B, Stephen J: Hidradenitis suppurativa treated with finasteride. J Dermatolog Treat. 2005 Apr;16(2):75-8. |
| Groups | Approved |
| Direct Classification | Androgens and derivatives |
| SMILES | [H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])NC(=O)C=C[C@]12C |
| Pathways | |
| PharmGKB | PA449627 |
| ChEMBL | CHEMBL710 |
