| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10044628 | HBV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS30065370 | HIV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS30065371 | HIV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS30065372 | HIV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS30065373 | HIV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS30065374 | HIV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS30065375 | HIV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS20020600 | HPV | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
| TVIS44025781 | HTLV-1 | ENSG00000112742.10 | protein_coding | TTK | No | No | 7272 | P33981 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | TTK |
|---|---|
| DrugBank ID | DB15498 |
| Drug Name | BOS172722 |
| Target ID | BE0003791 |
| UniProt ID | P33981 |
| Regulation Type | inhibitor |
| PubMed IDs | 30199249; 31575759 |
| Citations | Woodward HL, Innocenti P, Cheung KJ, Hayes A, Roberts J, Henley AT, Faisal A, Mak GW, Box G, Westwood IM, Cronin N, Carter M, Valenti M, De Haven Brandon A, O'Fee L, Saville H, Schmitt J, Burke R, Broccatelli F, van Montfort RLM, Raynaud FI, Eccles SA, Linardopoulos S, Blagg J, Hoelder S: Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N(2)-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N(8)-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722). J Med Chem. 2018 Sep 27;61(18):8226-8240. doi: 10.1021/acs.jmedchem.8b00690. Epub 2018 Sep 10.@@Anderhub SJ, Mak GW, Gurden MD, Faisal A, Drosopoulos K, Walsh K, Woodward HL, Innocenti P, Westwood IM, Naud S, Hayes A, Theofani E, Filosto S, Saville H, Burke R, van Montfort RLM, Raynaud FI, Blagg J, Hoelder S, Eccles SA, Linardopoulos S: High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. Mol Cancer Ther. 2019 Oct;18(10):1696-1707. doi: 10.1158/1535-7163.MCT-18-1203. |
| Groups | Experimental |
| Direct Classification | |
| SMILES | CCOC1=CC(=CC=C1NC1=NC=C2C=C(C)N=C(NCC(C)(C)C)C2=N1)C1=NN=CN1C |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3924132 |
