| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20050374 | HPV | ENSG00000167552.16 | protein_coding | TUBA1A | No | No | 7846 | Q71U36 |
| TVIS44017501 | HTLV-1 | ENSG00000167552.16 | protein_coding | TUBA1A | No | No | 7846 | Q71U36 |
| TVIS44033963 | HTLV-1 | ENSG00000167552.16 | protein_coding | TUBA1A | No | No | 7846 | Q71U36 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TUBA1A |
|---|---|
| DrugBank ID | DB00643 |
| Drug Name | Mebendazole |
| Target ID | BE0001340 |
| UniProt ID | Q71U36 |
| Regulation Type | inhibitor |
| PubMed IDs | 8139621; 15500920; 11444621; 12099434; 17662615; 10592235 |
| Citations | Lubega GW, Geary TG, Klein RD, Prichard RK: Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole. Mol Biochem Parasitol. 1993 Dec;62(2):281-92.@@MacDonald LM, Armson A, Thompson AR, Reynoldson JA: Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum. Mol Biochem Parasitol. 2004 Nov;138(1):89-96.@@Oxberry ME, Gear TG, Prichard RK: Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus. Parasitology. 2001 Jun;122(Pt 6):683-7.@@Ochola DO, Prichard RK, Lubega GW: Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro. J Parasitol. 2002 Jun;88(3):600-4.@@Wampande EM, Richard McIntosh J, Lubega GW: Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude. Protein Expr Purif. 2007 Oct;55(2):236-45. Epub 2007 Apr 25.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
| Groups | Approved; Vet_approved |
| Direct Classification | Benzophenones |
| SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | PA164776669 |
| ChEMBL | CHEMBL685 |
