| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30008025 | HIV | ENSG00000101162.4 | protein_coding | TUBB1 | No | No | 81027 | Q9H4B7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TUBB1 |
|---|---|
| DrugBank ID | DB01248 |
| Drug Name | Docetaxel |
| Target ID | BE0000026 |
| UniProt ID | Q9H4B7 |
| Regulation Type | |
| PubMed IDs | 15161985; 18559268; 11309480; 15698529 |
| Citations | Gligorov J, Lotz JP: Preclinical pharmacology of the taxanes: implications of the differences. Oncologist. 2004;9 Suppl 2:3-8.@@Matesanz R, Barasoain I, Yang CG, Wang L, Li X, de Ines C, Coderch C, Gago F, Barbero JJ, Andreu JM, Fang WS, Diaz JF: Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel. Chem Biol. 2008 Jun;15(6):573-85. doi: 10.1016/j.chembiol.2008.05.008.@@Snyder JP, Nettles JH, Cornett B, Downing KH, Nogales E: The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5312-6. Epub 2001 Apr 17.@@Belani CP, Eckardt J: Development of docetaxel in advanced non-small-cell lung cancer. Lung Cancer. 2004 Dec;46 Suppl 2:S3-11. |
| Groups | Approved; Investigational |
| Direct Classification | Taxanes and derivatives |
| SMILES | [H][C@@]1(C[C@@]2(O)[C@@H](OC(=O)C3=CC=CC=C3)[C@]3([H])[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C(=C1C)C2(C)C)OC(C)=O)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C1=CC=CC=C1 |
| Pathways | Docetaxel Action Pathway |
| PharmGKB | PA449383 |
| ChEMBL | CHEMBL92 |
