| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30047795 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047796 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047797 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047798 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047799 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047800 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30020437 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047801 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047802 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
| TVIS30047803 | HIV | ENSG00000130816.17 | protein_coding | DNMT1 | Yes | No | 1786 | I6L9H2 P26358 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | DNMT1 |
|---|---|
| DrugBank ID | DB01099 |
| Drug Name | Flucytosine |
| Target ID | BE0000892 |
| UniProt ID | P26358 |
| Regulation Type | other |
| PubMed IDs | 17139284; 17016423; 17897676; 8441637 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Shieh FK, Reich NO: AdoMet-dependent methyl-transfer: Glu119 is essential for DNA C5-cytosine methyltransferase M.HhaI. J Mol Biol. 2007 Nov 9;373(5):1157-68. Epub 2007 Aug 19.@@Wyszynski MW, Gabbara S, Kubareva EA, Romanova EA, Oretskaya TS, Gromova ES, Shabarova ZA, Bhagwat AS: The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA binding. Nucleic Acids Res. 1993 Jan 25;21(2):295-301. |
| Groups | Approved; Investigational |
| Direct Classification | Halopyrimidines |
| SMILES | NC1=C(F)C=NC(=O)N1 |
| Pathways | |
| PharmGKB | PA449654 |
| ChEMBL | CHEMBL1463 |
