| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44026744 | HTLV-1 | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS44010098 | HTLV-1 | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS44020528 | HTLV-1 | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | GRIN2B |
|---|---|
| DrugBank ID | DB00949 |
| Drug Name | Felbamate |
| Target ID | BE0000417 |
| UniProt ID | Q13224 |
| Regulation Type | antagonist |
| PubMed IDs | 10215667; 10690753; 11752352; 18311896; 18253065 |
| Citations | Kleckner NW, Glazewski JC, Chen CC, Moscrip TD: Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action. J Pharmacol Exp Ther. 1999 May;289(2):886-94.@@Harty TP, Rogawski MA: Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39(1):47-55.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Chang HR, Kuo CC: Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor. J Med Chem. 2008 Mar 27;51(6):1534-45. doi: 10.1021/jm0706618. Epub 2008 Feb 27.@@Luszczki JJ, Danysz W, Czuczwar SJ: Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model. Pharmacology. 2008;81(3):259-65. doi: 10.1159/000114870. Epub 2008 Feb 4. |
| Groups | Approved |
| Direct Classification | Benzene and substituted derivatives |
| SMILES | NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 |
| Pathways | Felbamate Metabolism Pathway |
| PharmGKB | PA449590 |
| ChEMBL | CHEMBL1094 |
