| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44020351 | HTLV-1 | ENSG00000152402.11 | protein_coding | GUCY1A2 | No | No | 2977 | P33402 |
| TVIS44033383 | HTLV-1 | ENSG00000152402.11 | protein_coding | GUCY1A2 | No | No | 2977 | P33402 |
| TVIS44017263 | HTLV-1 | ENSG00000152402.11 | protein_coding | GUCY1A2 | No | No | 2977 | P33402 |
| TVIS44012250 | HTLV-1 | ENSG00000152402.11 | protein_coding | GUCY1A2 | No | No | 2977 | P33402 |
| TVIS44046578 | HTLV-1 | ENSG00000152402.11 | protein_coding | GUCY1A2 | No | No | 2977 | P33402 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GUCY1A2 |
|---|---|
| DrugBank ID | DB09241 |
| Drug Name | Methylene blue |
| Target ID | BE0003578 |
| UniProt ID | P33402 |
| Regulation Type | inhibitor |
| PubMed IDs | 21547182; 27047301; 10439772; 19760660 |
| Citations | Ginimuge PR, Jyothi SD: Methylene blue: revisited. J Anaesthesiol Clin Pharmacol. 2010 Oct;26(4):517-20.@@Evora PR: Methylene Blue Is a Guanylate Cyclase Inhibitor That Does Not Interfere with Nitric Oxide Synthesis. Tex Heart Inst J. 2016 Feb 1;43(1):103. doi: 10.14503/THIJ-15-5629. eCollection 2016 Feb.@@Masaki E, Kondo I: Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats. Anesth Analg. 1999 Aug;89(2):484-9. doi: 10.1097/00000539-199908000-00045.@@Oz M, Lorke DE, Hasan M, Petroianu GA: Cellular and molecular actions of Methylene Blue in the nervous system. Med Res Rev. 2011 Jan;31(1):93-117. doi: 10.1002/med.20177. |
| Groups | Approved; Investigational |
| Direct Classification | Benzothiazines |
| SMILES | [Cl-].CN(C)C1=CC2=[S+]C3=C(C=CC(=C3)N(C)C)N=C2C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL405110 |
