| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30040827 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30040828 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS20007386 | HPV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS20013342 | HPV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS44008681 | HTLV-1 | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS44051217 | HTLV-1 | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ITGAL |
|---|---|
| DrugBank ID | DB00641 |
| Drug Name | Simvastatin |
| Target ID | BE0000516 |
| UniProt ID | P20701 |
| Regulation Type | inhibitory allosteric modulator |
| PubMed IDs | 15041742; 11385505; 15822172; 16828882 |
| Citations | Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23.@@Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058.@@Liao JK, Laufs U: Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89-118. doi: 10.1146/annurev.pharmtox.45.120403.095748.@@Fujii T, Masuyama K, Kawashima K: Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. J Neuroimmunol. 2006 Oct;179(1-2):101-7. Epub 2006 Jul 10. |
| Groups | Approved |
| Direct Classification | Delta valerolactones |
| SMILES | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC |
| Pathways | Simvastatin Action Pathway |
| PharmGKB | PA451363 |
| ChEMBL | CHEMBL1064 |
